Tirzepatide: An Effective Drug for Type 2 Diabetes and Possi-bility of Effecting Cardiovascular System
Awid mshain Almutiry, Saleh abdullah Alshahrani, Khaled mhthar Alkaf.
Abstract
Diabetes is a group of metabolic diseases characterized by hyperglycemia resulting from defects in insulin secretion, insulin action, or both. several pharmacological groups are used to treat type 2 diabetes mellitus (T2DM); however, the US Food and Drug Administration (FDA) recently ap-proved tirzepatide.
Functional, Biophysical, and Structural Characterization of Human IgG1 and IgG4 Fc Variants with Ablated Immune Functionality.
Susan H. Tam, Stephen G. McCarthy, Anthony A. Armstrong, Sandeep Somani.
Abstract
Engineering of fragment crystallizable (Fc) domains of therapeutic immunoglobulin (IgG) antibodies to eliminate their immune effector functions while retaining other Fc characteristics has numerous applications, including blocking antigens on Fc gamma (Fcγ)
Pathogenic and Protective Autoantibodies in Autoimmune Polyendocrinopathy-Candidiasis-Ectodermal Dystrophy (APECED).
Sakeen W. Kashem and Bryce A. Binstadt.
Abstract
Autoimmune polyendocrinopathy-candidiasis-ectodermal dystrophy (APECED) is a rare disorder caused by mutations in the autoimmune regulator (AIRE) gene, leading to defects in T cell selection.
Potential Roles of Antiphospholipid Antibodies in Generating Platelet-C4d in Systemic Lupus Erythematosus.
Chau-Ching Liu, Travis Schofield, Amy Tang, Susan Manzi.
Abstract
Premature, accelerated onset of atherothrombotic disease is prevalent in patients with systemic lupus erythematosus (SLE). Most, if not all, atherothrombotic diseases are likely to involve platelets and complement.
Strategies for Selecting Membrane Protein-Specific Antibodies using Phage Display with Cell-Based Panning.
Mohamed A. Alfaleh, Martina L. Jones, Christopher B. Howard.
Abstract
Membrane proteins are attractive targets for monoclonal antibody (mAb) discovery and development. Although several approved mAbs against membrane proteins have been isolated from phage antibody libraries, the process is challenging.