The Potentiality of Natural Compounds on Preventing α-synuclein aggregation: In silico-assisted Virtual screening for New Treatment Option in Parkinson’s Disease.
Ahmed Salem Alharbi1, Abdulaziz Adel Alshamsi2, Musab Saeed Khamisah.
Abstract
Parkinson's disease (PD) is an unexplained nervous system disorder that manifests in the motor and non-motor systems. It is a long-term, progressive neurodegenerative disease that usually impacts the elderly but can also strike people at an earlier age in life.
Chemical Composition and Antioxidant Properties of Juniper Berry (Juniperus communis L.) Essential Oil. Action of the Essential Oil on the Antioxidant Protection of Saccharomyces cerevisiae Model Organism.
Martina Höferl,Ivanka Stoilova,Erich Schmidt,Jürgen Wanner,Leopold Jirovetz,Dora Trifonova,Lutsian Krastev andAlbert Krastanov.
Abstract
The essential oil of juniper berries (Juniperus communis L., Cupressaceae) is traditionally used for medicinal and flavoring purposes. As elucidated by gas chromatography/flame ionization detector (GC/FID) and gas chromatography/mass spectrometry.
N-acetyl Cysteine Overdose Induced Acute Toxicity and Hepatic Micro-vesicular Steatosis by Disrupting GSH and Interfering Lipid Metabolisms in Normal Mice.
Ming-Shiun Tsai,Gunn-Guang Liou,Jiunn-Wang Liao,Pin-Yen Lai,Di-Jie Yang,Szu-Hua Wu, Sue-Hong Wang.
Abstract
N-acetyl cysteine (NAC) is a versatile drug used in various conditions, but the limitations and toxicities are not clear. The acute toxicity and toxicological mechanisms of an intraperitoneal injection of NAC in normal mice were deciphered. The LD50 for male and female BALB/cByJNarl mice were 800 mg/kg and 933 mg/kg.
The Treatment of Acute Diaphyseal Long-bones Fractures with Orthobiologics and Pharmacological Interventions for Bone Healing Enhancement: A Systematic Review of Clinical Evidence.
Giuseppe Marongiu,Andrea Contini,Andrea Cozzi Lepri,Matthew Donadu,Marco Verona, Antonio Capone.
Abstract
The healing of long bones diaphyseal fractures can be often impaired and eventually end into delayed union and non-union. A number of therapeutic strategies have been proposed in combination with surgical treatment in order to enhance the healing process.
Sleep, Plasticity and the Pathophysiology of Neurodevelopmental Disorders: The Potential Roles of Protein Synthesis and Other Cellular Processes.
Dante Picchioni,R. Michelle Reith,Jeffrey L. Nadel andCarolyn B. Smith.
Abstract
Sleep is important for neural plasticity, and plasticity underlies sleep-dependent memory consolidation. It is widely appreciated that protein synthesis plays an essential role in neural plasticity. Studies of sleep-dependent memory and sleep-dependent plasticity.