Original Article

Possibility of Inhibiting Epidermal Growth Factor Receptor (EGFR) Through Nerium oleander L. Extract to Prevent the Development of Non-Small Cell Lung Cancer

Obaid faris Aldossari, Saleh abdullah Alshahrani, Tallah Ibrahim Alkiady, Abdulrahman ibraihm Alzmael, Mohammed abdullah Alsugairan, Mohamad abdullah Altalha, Ali saeed Al dossari, Abdullah mansour Alzaid, Fawaz mofareh Gohal, Fahad qassem Gohal, Nada marzouq Alsharif, Mohammed rashed Alotaibi, Abrar Alasmari.

Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Health Information Department, Primary health care, Ministry of National Guard-Health Affairs, Dirab, Riyadh, Kingdom of Saudi Arabia.

Medical Record Department, Primary health care, Ministry of National Guard-Health Affairs, Dirab, Riyadh, Kingdom of Saudi Arabia.

Ministry of National Guard-Health Affairs, King Abdulaziz Medical City, Riyadh, Kingdom of Saudi Arabia.

Saudi Armed Forces Medical Services, Prince Sultan Medical City, Riyadh, Kingdom of Saudi Arabia.

Dental Service Department, Primary health care, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Primary health care, Ministry of National Guard-Health Affairs, Dirab, Riyadh, Kingdom of Saudi Arabia.

Address for correspondence: Abrar Alasmari. King Abdullah International Medical Research Center, Riyadh, Kingdom of Saudi Arabia.

Email: Abrar.alasmari@outlook.com

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Lung cancer is the most frequent cancer globally in terms of both incidence and mortality, with the highest rates found in Europe and North America. The age group with a history of smoking who is older than 50 is most likely to acquire lung cancer. There are 2 main forms of lung cancer: NSCLC (85% of patients) and small cell lung cancer (SCLC) (15%). It has been proposed that the immune system contributes to the pathophysiology of lung cancer, particularly in cases when immune surveillance is compromised. "Immunoediting" is the mechanism by which cancer cells evade the immune system. In addition to suppressing the immune response, EGFR mutations play a critical role in the progression of lung cancer. Nerium oleander L. is a significant traditional Chinese medicine. This attractive plant is grown vegetatively and is prized for its colorful terminal flower clusters and evergreen leaves. Anti-inflammatory, antibacterial, anticancer, antinocicep-tive, and central nervous system depressive properties are significant pharmacological actions. The objective of the current investigation is to determine whether the chemical composition of Nerium oleander L. can suppress the epidermal growth factor receptor (EGFR) in order to prevent non-small cell lung cancer (NSCLC) therefore, we employed a computational screening approach encompassing molecular docking, ADMET prediction to find the best active compound in Nerium oleander L. extract.

Keywords: Molecular docking; EGFR; Nerium oleander L; Non-small cell lung cancer.

Author Information

American Journal of Molecular Signaling