Original Article

Effect of Juglans regia L. Pollen on γ secretase for Preventing β-amyloid generation: New Treatment Option in Alzheimer’s Disease.

Saif sultan Alsahli, Awid mshain Almutiry, Obaid faris Aldossari, Nada abdullah Alotaibi, Norah musallam Aldosari, Albandari saad Almutairi, Haya mohammed Alqahtani, Fahad mohammed Alqahtani, Fahad sari Alanazi, Abdulrahman ibraihm Alzmael, Mohammed abdullah Alsugairan, Abrar Alasmari.

Author Information

Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Nursing Department, Primary health care, Ministry of National Guard-Health Affairs, Dirab, Riyadh, Kingdom of Saudi Arabia.

Aviation medicine unit, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Medical record Department, Primary health care, Ministry of National Guard-Health Affairs, Dirab, Riyadh, Kingdom of Saudi Arabia.

Address for correspondence: Abrar Alasmari. King Abdullah International Medical Research Center, Riyadh, kingdom of Saudi Arabia. Email: Abrar.alasmari@outlook.com

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Alzheimer's disease (AD) is a neurodegenerative disorder known as the primary cause of dementia that is rapidly rising to the top of the list of diseases in this twentieth century in terms of cost, mortality, and impact. Two primary pathogenic alterations in the brain are associated with AD: extracellular amyloid protein deposits with dystrophic neurites that form senile plaques and intracellular protein deposits known as neurofibrillary tangles (NFT). production of β-amyloid (Aβ) occurs within the cell when the secretase enzyme catalyst cleaves the amyloid precursor protein (APP). Aβ is created at the plasma membrane by the action of β and γ secretase on mature APP. Since γ-secretases are in the position of releasing Aβ from the intracellular region of APP, an extensive amount of research has been done on medications that can only partially minimize the activity of this enzyme. In this regard, we employed a computational screening approach encompassing molecular docking, ADMET prediction to find the best active compound in Juglans regia L. pollen extract that has the ability to effect γ secretase for Preventing β -amyloid generation.

Keywords: Computational modelling; γ secretase; Juglans regia L. pollen; Alzheimer's disease

American Journal of Molecular Signaling