Role of Cephalosporins in Targeting SLC7A11/xCT through In-silico-assisted Virtual screening: Underline Molecular Mechanism and Possibility of Innovative Treatment in Preventing Cardiotoxicity.
Saif sultan Alsahli, Awid mshain Almutiry, Obaid faris Aldossari.
Abestract
Cardiotoxicity is cardiomyopathy, which is characterized by a global or more severe decrease in left ventricular ejection fraction (LVEF), a decline in ejection fraction (EF) of less than 5% to a final ejection fraction of less than 55% with congestive heart failure.
De Novo Class of Momordicoside with Potent and Selective Tumor Cell Growth Inhibitory Activity as Pyruvate Kinase Muscle Isozyme 2 and Anti-apoptotic Myeloid Leukemia.
Tope Abraham Ibisanmi, Jamiu Olaseni Aribisala, Peace Ifeoma Odjegba.
Abstract
The difficulty in treating cancer resides in targeting abnormal proliferation while protecting normal proliferation, necessitating a thorough comprehension of the normal and malignant mechanisms that promote cell growth and proliferation.
Molecular Docking Studies of Phytoconstituents Identified in Traditional Siddha Polyherbal Formulations Against Possible Targets of SARS-CoV-2.
Logesh Kumar Selvaraj, Geethanjali Thayumanavan, Srikanth Jeyabalan, Sugin Lal.
Abestract
Traditional Medicines System has long used Siddha polyherbal formulations for different viral diseases. The ingredients of these formulas have been proven to be antiviral. The study focuses on in silico computational evaluation of phytoconstituents.
The Study of Potential Antiviral Compounds from Indonesian Medicinal Plants as Anti-COVID-19 with Molecular Docking Approach.
Baiq Ressa Puspita Rizma, Agus Dwi Ananto, Anggit Listyacahyani Sunarwidhi.
Abstract
Corona Virus Disease 2019 (COVID-19) is a new strain of coronavirus called SARS-CoV-2, which was identified in Wuhan, China, in December 2019. The rapid transmission of COVID-19 from human to human forced researchers to find a potent drug by setting aside.
Phytochemical Molecules Binding with the Proteins of Mycolic Acid Synthesis Pathway of Mycobacterium tuberculosis.
Rishabh Gaur, Praveen Kumar Anand.
Abstract
Resistance against anti-tubercular drugs is a significant problem. This elucidates the need for novel drug targets. Altering and targeting the enzymes involved in cell wall synthesis led to fatal damage to the bacterial cell.