Original Article

Stimulating Tumor Suppressor Gene p53 Through Using Active Compound in Achillea fragrantissima for Inhibit Progression of Brain Tumor: Utilizing Computer-Assisted Approaches

Naif M Alzahrani, Mishari Abdullah Alajery, Fahad Mohammed Alyousef, Faisal Hamed Almalki, Ibraheem Abdu Aljabray, Ali saeed Al dossari, Nada Abdullah Alotaibi, Yazeed Mohammed Alyamni, Hind Saad Alareefi, Danah Ahmed Alshehri, Haya Mohammed Alqahtani, Ali Aaly Almalki, Mutaz Fahad Alluhaydan.

Author Information

Internal Medicine Department, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Medical Record Department, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Radiology Department, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Patient Education Department, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Dietetics Department, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Nursing Department, Primary health care, Ministry of National Guard-Health Affairs, Dirab, Riyadh, Kingdom of Saudi Arabia.

Hemodialysis Care Project, Ministry of National Guard-Health Affairs, Riyadh, Kingdom of Saudi Arabia.

Address for correspondence: Naif M Alzahrani, Internal Medicine Department, Ministry of National Guard-Health Affairs.

Email: Alzahran12@hotmail.com

This is an open-access article distributed under the terms of the Creative Commons Attribution-Noncommercial-Share Alike 4.0 Unported, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

American Journal of Molecular Signaling

Abstract

A tumor, also called neoplasm or lesion is abnormal tissue that grows by uncontrolled cell division. One of the most dangerous cancers that affect people is a brain tumor. It is responsible for about 29.5% of cancer-related deaths and 1.35% of all malignant neoplasms. However, p53 exerts its tumor suppressive function by sensing cellular damage and integrating this signal into a response where cell cycle arrest and repair mechanisms take place, or where cell elimination by apoptosis or senescence occurs. Achillea fragrantissima (Forssk.) Sch.Bip (A. fragrantissima) (Synonym, Santolina fragrantissima Forssk.), which are known as traditional herbal medicine consumed by Middle Eastern populations. In this regard, we employed a computational screening approach encompassing molecular docking to find the best active compound in Achillea fragrantissima extract that has the ability to stimulate p53 for inhibiting the progression of brain tumor. The docking result showed that the binding energy of chosen Achillea fragrantissima compounds fall between -4.2 and -8.5 kcal/mol. Among these compounds Fortunellin and (+)-Epicatechin displayed the best binding ability against p53, returning binding energies of -8.5 and -7.1 kcal/mol. Furthermore, the in-vitro and in-vivo studies of protein and gene expression must be evaluated.

Keywords: Brain tumor; Tumor suppressor gene; p53; Molecular docking.